ONLY AVAILABLE AT

MEDIFACIAL APPROVED

PROFESSIONAL CLINICs

REMODELLING

Physically reach deep epidermis and dermis, re-model for rejuvenated, firmer, smoother skin.

BOOST SKIN QUALITY

Stimulate the skin’s natural metabolism for re-textured, evenly toned and less blemished quality.

ALL SKIN TYPES

Suitable for all skin phototypes with controlled application and downtime.

100-150μm biominerals

Clinical Aesthetics

01

02

03

Engineered biominerals for controlled dermal remodelling.

HYPERPIGMENTATION

Solar Elastosis/Melasma

ACNE

Acne/Scarring

AGEING

Laxity/Wrinkles

PORES

Closed Comedones/Congestion

REMODELLING

Deep Resurfacing/Body/Face/Neck

Product Name

Volume

SKU

Formula Driver ​Description

Efficacy

Medifacial Dermsculpt Bioneeding 1000

1g/5ml

783970077301

Engineered biomineral derivatives

The Dermasculpt Bioneedling 1000 is designed to transform the skin through creating over 1300 ​micro channels per square minimeter on the skin. Dermsculpt bioneedles are engineered from ​biomineral derivatives that are 100% bio degradable, leaving the skin through desquamation after ​86 hours. These bioneedles enter the skin through the stratum corneum during the dermal ​depositing procedure with circular motions. The bioneedles are capable of entering the dermis, ​stimulating desquamation and collagen synthesis, offering a unique approach to

combat hyperpigmentation, stimulate collagen synthesis, and unveil a radiant, youthful complexion.

Dermsculpt bioneedles are lab made biominerals designed to be 100-150 micrometers in length, 5-7 micrometers in diameter.

Dermsculpt Bioneedles reach the Stratum Basalis and dermis through circular motions for skin deposition.

This controlled approach makes it suitable to target both superficial skin blemishes and deep skin remodelling. The microchannels on the skin created

during the deposition gradually close over the course of 7-10 days, making it the prime time for active ingredient application for saturating skin cells.

Fig.1: Liposome saturation without bioneedling Fig 2: Liposome saturation with bioneedling.

5-7 micrometers in diameter

100-150 micrometers in length

1. Enhanced Collagen Synthesis

Stimulates the production of collagen, integral to the skin’s structure, leading to improved skin

elasticity and firmness. This results in a noticeable reduction of fine lines and wrinkles over time.

2. Effective Exfoliation and Hyperpigmentation Reduction

Offers a physical exfoliation that safely removes the outermost layer of dead skin cells, revealing

brighter, more even-toned skin underneath. It effectively diminishes hyperpigmentation, including

age spots, sun damage, and melasma, without the need for harsh chemical peels.

3. Minimized Pore Size

The process of bioneedling helps to unclog and refine the appearance of pores. This not only ​improves skin texture but also reduces the likelihood of acne breakouts by removing excess sebum ​and debris.

4. Improved Skin Texture and Tone

By removing the surface layer of dead skin and stimulating underlying tissues, Dermsculpt

Bioneedling smooths out rough textures and evens out skin tone, resulting in a smoother, more

radiant complexion.

5. Increased Product Absorption

The micro-channels created during the bioneedling process allow for deeper penetration of

skincare products. This maximizes the effectiveness of topical treatments by ensuring that active

ingredients reach the areas where they are most needed.

6. Scar and Stretch Mark Reduction

Regular treatments can lead to the gradual fading of scars and stretch marks. The collagen and

elastin production triggered by the procedure promote the regeneration of healthy skin cells, thus

diminishing the visibility of these concerns.

7. Supports Skin Healing and Regeneration

Initiates the skin’s natural healing process without the need for chemical substances, supporting

the regeneration of healthier, more resilient skin tissue.

8. Safe for All Skin Types

Engineered to be gentle and compatible with a wide range of skin types, including sensitive skin. It

minimizes the risk of adverse reactions commonly associated with more aggressive chemical or

laser treatments.

9. Minimally Invasive with Minimal Downtime

Offers a less invasive alternative to surgical procedures, with minimal to no downtime required.

Patients can typically resume their normal activities shortly after treatment.

10. Versatile Treatment

Suitable for addressing a multitude of skin concerns on various parts of the body, not just the face.

It can be effectively used on the neck, décolletage, hands, and other areas prone to signs of aging

or skin damage.

Skin Types

Dry ​Oily

Neutral ​Comedonal

Sensitive ​Resistant

Even ​Hyperpigmented

Lax ​Firm

Skin Concerns

1. Fine Lines and Wrinkles

Stimulates collagen production to reduce the appearance of fine lines and wrinkles, promoting ​smoother, more youthful-looking skin.

2. Hyperpigmentation and Uneven Skin Tone

User Profile

How to Use Ingredient Profile

Full ingredients:

Bioneedles: Calcium Carbonate, Silica

Activator: Aqua, Sodium Hyaluronate

Helps in fading dark spots, sun damage, and melasma by removing the outermost layer of the skin and promoting the growth of new, more evenly pigmented skin cells.

3. Scars

Effective in reducing the appearance of acne scars, surgical scars, and other types of skin blemishes

by encouraging the skin’s natural healing process and collagen synthesis, leading to smoother skin

texture.

4. Stretch Marks

Can improve the appearance of stretch marks by promoting the regeneration of the skin, making

them less noticeable over time.

5. Enlarged Pores

Helps to refine and minimize the appearance of large pores by improving skin elasticity and

encouraging the tightening of the skin around the pores.

6. Skin Texture Irregularities

Smooths rough or uneven skin textures by exfoliating the outer skin layer and promoting cellular

renewal for a more refined skin surface.

7. Dull Skin

Revitalizes dull, tired-looking skin by removing dead skin cells and enhancing the skin’s natural

luminosity.

8. Acne and Oily Skin

The treatment can help manage acne and reduce oiliness by unclogging pores, removing excess

sebum, and promoting a balanced skin environment.

9. Preventative Aging

Regular treatments can act as a preventative measure against the early signs of aging by

maintaining high levels of collagen and elastin in the skin.

10. Dehydrated Skin

By improving the skin's ability to absorb and retain moisture, Dermsculpt Bioneedling can enhance

hydration levels, leading to plumper, more hydrated skin.

11. Sensitivity and Redness

For some, the treatment can improve the resilience of sensitive skin over time, reducing

susceptibility to redness and irritation.

Individuals looking to correct deep skin blemishes with minimal downtime.

Refer to the Clinical Protocol

Calcium Carbonate

Source: Derived from marine organisms and sedimentary rock formations, calcium carbonate is a

natural mineral known for its purity and versatility. Engineered for dimensions and biocompatibility.

Benefits:

Exfoliation: Gently removes dead skin cells to reveal a smoother, brighter complexion underneath. pH Balance: Helps maintain the skin's natural pH balance, promoting a healthier skin barrier and

reducing the risk of irritation.

Mineralization: Contributes essential minerals to the skin, fostering a revitalized and more vibrant

skin appearance.

Silica

Source: Sourced from the earth’s crust, silica is a fundamental component of sand and quartz,

renowned for its strength and resilience. Engineered for dimensions and biocompatibility.

Benefits:

Structural Support: Strengthens the skin’s connective tissues, enhancing firmness and elasticity for

amore youthful look.

Moisture Retention: Binds to water molecules, improving hydration levels in the skin for a plump,

dewy finish.

Pore Refinement: Minimizes the appearance of pores by supporting skin structure and promoting a

smooth, refined texture.

The Bioneedling Technology

Dermsculpt Bioneedling employs engineered bioneedles crafted from these mineral derivatives,

designed to penetrate the skin’s surface gently. This innovative technology accomplishes what

traditional skincare cannot—direct delivery of rejuvenating minerals into the deeper layers of the

skin.

Sustainability and Safety

Committed to sustainability, Dermsculpt Bioneedling uses only the finest, ethically sourced

minerals, ensuring that every treatment is not only kind to your skin but also to the environment.

The natural origin of calcium carbonate and silica ensures compatibility with the skin’s biological

processes, reducing the risk of adverse reactions and promoting long-term skin health.

Delivery Method

How it Works

The delivery method of Dermsculpt Bioneedling involves an innovative and targeted approach, utilizing engineered bioneedles made from natural mineral derivatives. These bioneedles are the core component that facilitates the direct and efficient delivery of rejuvenating agents into the skin.

Engineered Bioneedles: These bioneedles are precisely designed to create micro-channels in the

skin's surface without causing extensive damage to the skin tissue. The bioneedles enter the skin

through pressured motions by massage.

Controlled Penetration: The bioneedles penetrate the epidermis (the outer layer of the skin) and

reach the dermis, the layer beneath, where most skin aging occurs and where collagen and elastin

fibers are located. This controlled penetration is crucial for ensuring that the active ingredients are

delivered directly to the target area, maximizing their effectiveness.

Once the bioneedles are deposited into the skin, they remain in the skin for 72-86 hours. During

this period of time, the bioneedles get metabolised by the skin, their edges are dissolved and

become mineral metabolites, so they come off along with the peeling dead skin.

Stimulation Process

The deposited bioneedles cannot get absorbed by bloodstream due to the molecular size, they

remain in the skin to stimulate for cellular rejuvenation until they get metabolised. During the 3-4

days period of time, they stimulate collagen and natural peptide growth, so the damaged skin get

rapidly renewed and the volume becomes fuller. Due to the physical actions, the peeling process

associated with Dermsculpt Bioneedling is fundamentally different from chemical peels. Instead of

using acids to dissolve dead skin cells and induce peeling, Dermsculpt Bioneedling relies on a

physical mechanism:

Physical Exfoliation and Removal of Dead Skin Cells: The action of the bioneedles effectively

removes the outermost layer of dead skin cells through physical exfoliation. This process uncovers

Contraindications ​Storage

Product Development ​Science

the newer, healthier skin beneath and can lead to a mild peeling effect as the old, dead skin cells

are shed naturally.

Cellular Turnover Acceleration: By stimulating the natural healing response, Dermsculpt

Bioneedling accelerates the rate of cellular turnover. New skin cells are produced more rapidly,

pushing the older, damaged cells to the surface where they eventually peel off. This turnover is

crucial for improving skin texture, tone, and overall appearance.

Why Would the Skin Peel Off?

Natural Exfoliation Process: The peeling is a part of the skin's natural process of renewal. As the

bioneedles work to accelerate skin regeneration, the shedding of the outermost layer is a normal,

expected phase, allowing for the emergence of fresher, revitalized skin.

Elimination of Damaged Skin Cells: The peeling helps in removing cells that have been damaged

by sun exposure, aging, and environmental factors, making way for healthier skin cells and

reducing signs of aging, hyperpigmentation, and other skin concerns.

Enhancement of Skin's Appearance: Through this controlled peeling process, Dermsculpt

Bioneedling facilitates a more uniform skin texture and tone, reducing imperfections and revealing

asmoother, more youthful complexion.

●Allergy to ingredient

Tightly capped and stored in a cool, dry place below 25 degrees Celsius. Keep out of direct sunlight

to preserve the integrity of the ingredients.

The development of Dermsculpt Bioneedling represents an advancement in treating stubborn skin

concerns such as acne, hormonal related hyperpigmentation and wrinkles, blending precision

engineering with deep biological insights to create a product that offers targeted, effective, and

safe skin rejuvenation.

Engineered Bioneedles: Precision and Safety

Precision Engineering: The bioneedles used in Dermsculpt Bioneedling are engineered with

controlled dimensions, allowing for precise control over the depth of skin penetration. This

precision ensures that the treatment can effectively reach and rejuvenate the dermal layer, where

collagen and elastin fibers reside, without causing unnecessary damage to the skin's surface.

Controlled Depth: By carefully controlling the penetration depth, Dermsculpt Bioneedling

minimizes the risk of infection, inflammation, and other complications associated with deeper skin

injuries. This controlled approach also contributes to the product's excellent safety profile, making

it suitable for a wide range of skin types.

Skin Renewal and Long Term Benefits

Stimulation of Natural Healing Processes: The micro-channels created by the bioneedles initiate a

natural healing response, including the activation of fibroblasts and increased production of

collagen and elastin. This not only accelerates skin renewal but also improves the skin’s structural

integrity over time.

Sustained Metabolic Benefits: Regular use of Dermsculpt Bioneedling can lead to sustained

improvements in skin metabolism, promoting continuous skin rejuvenation and maintenance of the

dermal matrix. These long-term benefits result in lasting firmness, elasticity, and a significant

reduction in the appearance of wrinkles and fine lines.

Effective Against Hyperpigmentation: For those dealing with hormonal related hyperpigmentation,

such as melasma, the precise action of the bioneedles offers a way to rejuvenate the skin and

lighten hyperpigmentation without triggering additional hormonal imbalances or sensitivity, often

exacerbated by chemical treatments.

Product Name

Volume

SKU

Formula Driver ​Description

Efficacy

Medifacial Dermsculpt Bioneeding 600A

1g/5ml

783970077325

Engineered biomineral derivatives + Chlorella Vulgaris, Chlorophyll, Spirulina Maxima

The Dermasculpt Bioneedling 600A leverages advanced micro-biomineral technology to administer ​potent anti-inflammatory agents, offering significant antioxidant benefits. This innovative ​formulation is specifically designed to alleviate pore congestion and diminish the symptoms of acne ​vulgaris. By enhancing the bio-environment of the epidermis, it promotes the emergence of ​healthier, more resilient skin.

50-150μm micro-minerals create micro-channels in the skin, enhancing ​the penetration of active ingredients. This mechanism facilitates deeper ​delivery and increased efficacy of the treatment, promoting rapid healing ​and reduction of inflammation associated with sebum and acne.

Chlorella Vulgaris: Renowned for its detoxifying properties, Chlorella ​vulgaris is rich in vitamins and minerals that nourish the skin. Its high ​levels of vitamins A, C, and E, alongside essential fatty acids, significantly ​improve skin's elasticity and texture while reducing the proliferation of ​bacteria responsible for acne outbreaks.

Chlorophyll: Acting as a natural healer, chlorophyll helps in reducing ​inflammation and bacterial growth in acne-prone skin. Its wound-healing ​properties accelerate the repair process of damaged skin, and its ability to ​inhibit the growth of Propionibacterium acnes, the bacteria directly ​involved in acne formation, is crucial for maintaining clear skin.

Spirulina Maxima: This blue-green algae is a powerhouse of antioxidants ​that combat oxidative stress, one of the contributors to acne and ​premature aging. Spirulina's high content of gamma-linolenic acid (an ​essential fatty acid) helps in soothing the skin and reducing inflammatory ​responses that lead to acne and closed comedones.

Together, these ingredients make Dermasculpt a potent solution for reducing acne and closed ​comedones. The combined action of these natural compounds not only clears the skin of existing ​blemishes but also prevents new ones from forming. By improving cellular turnover, enhancing ​skin detoxification, and providing essential nutrients, this formulation supports a healthier, ​clearer complexion.

EDUCATIONAL MATERIAL ONLY

Product Name

Volume

SKU

Formula Driver ​Description

Efficacy

Medifacial Dermsculpt Bioneeding 600B

1g/5ml

783970077332

Engineered biomineral derivatives + Fucoidan, E.Cava

Bioneedling with Fucoidan and Ecklonia Cava (E.Cava) offers a clinically effective solution for ​reversing the signs of photoaging and enhancing the complexion's brightness. Fucoidan, a sulfated ​polysaccharide derived from brown seaweed, possesses strong anti-inflammatory and antioxidant ​properties, which are essential in mitigating the dermal degradation caused by UV exposure.

50-150μm micro-minerals create micro-channels in the skin, enhancing the ​penetration of active ingredients. This mechanism facilitates deeper delivery and ​increased efficacy of the treatment, promoting rapid healing and reduction of ​inflammation associated with sebum and acne.

Fucoidan: Extracted from brown seaweed, Fucoidan is celebrated for its powerful ​anti-inflammatory and antioxidant properties. It plays a critical role in mitigating the ​effects of skin hyperpigmentation by inhibiting tyrosinase, an enzyme involved in ​the production of melanin. This inhibition helps in the reduction of dark spots and ​evens out the skin tone. Furthermore, Fucoidan enhances the skin’s natural barrier, ​improving its resilience against environmental stressors and preventing further ​pigmentation issues.

Ecklonia Cava (E.Cava): This marine algae is rich in phlorotannins, potent ​antioxidants that protect the skin against oxidative stress induced by UV radiation ​and other environmental aggressors. E.Cava is particularly effective in reducing the ​photo-aging effects on the skin, such as wrinkles and fine lines. Its antioxidant ​activity helps in reversing the damage caused by UV rays, promoting a more ​uniform skin tone and enhancing the skin's luminosity.

Together, Fucoidan and E.Cava in the Dermasculpt Bioneedling system provide a dual approach to ​skin care: they not only address the aesthetic concerns of hyperpigmentation and uneven skin tone ​but also bolster the skin’s defense mechanisms against future damage. This innovative treatment ​accelerates the skin's natural healing processes, leading to visibly brighter, clearer, and more ​youthful looking skin with enhanced protection against the elements.

EDUCATIONAL MATERIAL ONLY

Materials:

• Dermsculpt Bioneedling #1 and #2
• Bowl or plate
• Gloves
• Skintide PRF #1 and #2, or Phytotide CRF
• Cleanser
• Gauze/cotton pads/Protective eyewear

2

Skin Preparation:

• Cleanse and Exfoliate: Thoroughly remove makeup and cleanse the skin. Follow with an ​exfoliation using ACTIVITA Pore Prep Pad or Clarifier Hydro Exfoliator, particularly focusing on ​congested areas such as the forehead, nose, and chin.
  
• Dry the Skin: Use cotton pads, gauze, or a Facepal to dry the skin.
  
• Protect the Eyes: Cover the patient's eyes with protective gauze, cotton pads, or goggles.
  

Dermsculpt Bioneedling Preparation:

• Safety Measures: Wear disposable gloves, wash gloved hands, and dry them.
  
• Mixing the Components: Pour the Bioneedling Peel #1 onto a plate or bowl. Add the Activator ​#2 and mix with a gloved finger until a consistent paste forms. Minimum amount for full face: ​50%. Unmixed product must be stored in a cool dry location and can last up to 30 days.
  

Dermsculpt Bioneedling Procedure:

1. Delivery:
   

Dab the Dermsculpt paste with your fingers and gently massage onto the forehead in circular ​motions until absorbed. Repeat until the forehead is fully treated.

Continue to treat other areas in a similar manner, including the nose, chin, jawlines, temples, ​upper lips, nasolabial folds, and cheeks.

Notes on Delivery:

Use superficial motions only; Avoid pressurized motions.

Ensure that the motions are stopped once erythema is achieved.

1 Deposit/Pass means when erythema starts appearing (or with 30 motions). Only perform the 2nd ​deposit on areas of concerns (Acne, scarring, hyperpigmentation).

Expected Skin Reaction:

Mild erythema and frosting are normal reactions.

If pinpoint bleeding happens or skin peels during the treatment, then excessive swelling, blistering ​and scabbling may occur post treatment, and prolonged recovery time should be expected.

2. Re-activation:

Skintide PRF: Pour #2 Active Solvent into #1 Polypeptide powder, shake well, install a dropper tube, ​and apply 3-5 drops to each area, patting until the entire face is saturated.

Phytotide CRF: Break one ampoule and pat evenly onto the entire face.

Once concluded, do not apply any other product, including sunscreen.

Delivery reference map

Materials:

• Dermsculpt Bioneedling #1 and #2
• Bowl or plate
• Gloves
• Skintide PRF #1 and #2, or Phytotide CRF
• Cleanser
• Gauze/cotton pads/Protective eyewear

2

Post Procedure Care

Products

Cleansing: H4O Resolve HD Cleanser + Facepal

Exfoliate: Clarifier Hydro Exfoliator

Target: Phytotide CRF, ACTIVITA B for acne or C for Ageing/Hyperpigmentation

Masque: BE Active Masque

Hydration: Molecular Hydrator

Barrier Repairing: Vital Cream, ACTIVITA Hydro Zinc SPF 50

Day 0 (Day of Procedure):

Skin Reaction: Redness, darkening, pinpoing bleeding in rare cases, sore to touch.

Avoid sauna, steaming, hot environments, and strenuous exercises.

Apply zinc based sunscreen only. Avoid makeup. Do no wash face.

Avoid transferring bioneedles to the eyes when wiping them.

Days 1-2:

Skin Reaction: Redness, darkening, scabbing, dry, itchy.

Gently rinse face with H4O Resolve HD. Do not wipe or attempt to remove residual sunscreen.

Apply one ampoule of Phytotide CRF morning and night, or ACTIVITA B (for acne skin) or ACTIVITA C (for ageing and hyperpigmentation).

Apply a thick layer of Molecular Hydrator and B.E Active Masque to boost desquamation.

Apply a thick layer of Vital Cream to seal in hydration.

Avoid makeup, sauna, steaming, hot environments, and strenuous exercises.

Avoid transferring bioneedles to the eyes when wiping them.

Days 3-4:

Skin Reaction: Redness, darkening, peeling

Wash the face gently with water and a cleanser.

Apply one ampoule of Phytotide CRF or ACTIVITA B/C, morning and night.

Apply a thick layer of Molecular Hydrator and B.E Active Masque.

Apply hydro zinc sunscreen

Apply a thick layer of Vital Cream.

Days 5-6:

Renewed Skin feels normal to touch; Majority peeling concludes

Continue the aftercare skin routine. Use Clarifier Hydro Exfoliator to remove dead skin.

Return to normal lifestyle.

Skin peeling should mostly be complete, with minor desquamation continuing.

The skin should feel firmer, tighter, and clearer.

2

Dermsculpt Bioneedling 1000

Treatment Summary Sheet

Pre-Post Treatment Care (6 weeks prior to treatment until the day of treatment. Do ​not provide exfoliation during treatment if it’s done within 24 hours at home)

Pre-treatment care ensures the maximum effectiveness of the Dermsculpt ​treatment, and reduces the chance of having post treatment side effects. For Post-​treatment care, use the same routine but avoid acid/exfoliation before peeling.

Essential Care Products for Hyperpigmentation

Morning

H4O Resolve HD, Facepal

ACTIVITA C

Dermatology Formula Photo Corrector

Hydro Zinc SPF50

Vital Cream for dry skin

Plus Radiance AHA Toner throughout the day ​Optional: B.E Active Masque

Night

H4O Resolve HD, Facepal

Clarifier Hydro Exfoliator 2-3 days/week

Clarifier Enzy Treatment 2-3 days/week

Dermatology Formula Evolve

Vital Cream for dry skin

Plus Radiance AHA Toner throughout the day ​Optional: B.E Active Masque

Essential Care Products for Acne/Comedones/Congestion/Acne Scarring

Morning

H4O Resolve HD, Facepal

ACTIVITA Pore Prep Pads

ACTIVITA B

Dermatology Formula Photo Corrector

Hydro Zinc SPF50

Molecular Hydrator for dry skin

Minus Blemish BHA Toner throughout the day ​Optional: B.E Active Masque

Night

H4O Resolve HD, Facepal

Clarifier Hydro Exfoliator 2-3 days/week

Clarifier Enzy Treatment 2-3 days/week

ACTIVITA A or Evolve

Molecular Hydrator for dry skin

Minus Blemish BHA Toner throughout the day ​Optional: B.E Active Masque

Essential Care Products for Ageing

Morning

H4O Resolve HD, Facepal

ACTIVITA C

Dermatology Formula Glyca

Molecular Hydrator

Hydro Zinc SPF50

Vital Cream for dry skin

Divide Age Peptide Toner throughout the day ​Optional: B.E Active Masque

Night

H4O Resolve HD, Facepal

Clarifier Hydro Exfoliator 2-3 days/week

Clarifier Enzy Treatment 2-3 days/week

Molecular Hydrator

Dermatology Formula Evolve

Vital Cream for dry skin

Divide Age Peptide Toner throughout the day ​Optional: B.E Active Masque

Treatment Frequency:

Follow the general contraindication guidelines. Avoid the next treatment before the ​skin is fully recovered. It generally takes 4-6 weeks to fully recover without any ​erythema. It can take longer depending on the skin condition.

DERMSCULPT

BIONEEDLING

STEP BY STEP INSTRUCTIONS

Pour #1 bioneedles (peel powder) to a container

Pour #2 activator to

the container

MIX EVENLY WITH A FINGER OR A TOOL

MARK THE AREAS TO AVOID (ECZEMA PATCHES ETC)

PERFORM BY AREA, UNTIL THE FULL FACE IS TREATED. FROSTING SHOULD OCCUR 2-3MINS AFTER ERYTHEMA.

APPLY SKINTIDE PRF OR A CORRECTIVE SOLUTION.

CONCLUDE THE TREATMENT ONCE A UNIFORM ERYTHEMA/FROSTING IS ACHIEVED.